2 replies to this topic

[ImmInst]

Obesity Exerts an Epigenetic Effect on Muscle Stem Cells http://buff.ly/2lWChnb 

View the tweet

[YOLF]

Very interesting. I do hope they do the follow up study they mention (or I'll have to go look for it), and it would be nice if they do another follow up of healthy teenage cells. I know there has been some preliminary experiments involved in demethylation of specific genes, but what can demethylate more broadly without causing any damage? Whatever it is, is seemingly rare, but it would seem to happen in reproductive cells, so perhaps proximity to high levels of sex hormones is the trick. Those things which have been most successful at healthy demethylation have been sex hormone precursors such as diosgenin, testosterone (more brown fat), viagra (turning white fat into beige apparently via increased testosterone, reducing fat expansion inflammation, and leading to weight loss), moclobemide (also an MAOA/B inhibitor that upregulates sex hormone synthesis).

Anyone know what the title of this publication is?

[YOLF]

This looks like an interesting paper:

Transcriptional and epigenetic control of brown and beige adipose cell fate and function